George D. Bachand
Scientist, Center for Integrated Nanotechnologies
Science Thrust:: Soft and Biological Nanomaterials
P.O. Box 5800, MS1303
Sandia National Laboratories
Albuquerque, NM 87185-1303
Education and Training
Undergraduate: Elizabethtown College B.S. Biology, 1992
Graduate: State University of New York, Ph.D. Biology, 1997
George’s research interests have focused on engineering interfaces between biological and synthetic components to develop nanocomposite materials and integrated devices/systems. Much of this work relies on motor proteins and cytoskeletal filaments as nanofluidic transporters in sensor devices and as “dynamic assemblers” of nanostructured materials. Additionally, my laboratory’s work involves isolating and engineering biomolecular components with functional handles that may be used to integrate DNA, proteins, lipids, and cells into hybrid assemblies. Genetic engineering techniques are also used to introduce new functionality or control into biomolecular components. Recently, we have begun work to establish fundamental correlations between the physical and chemical properties of engineered nanoparticles and the biochemical and biophysical response of membranes and cells.
- Carroll-Portillo, A., and Bachand, G.D. (2009). Directed attachment of antibodies to kinesin-powered molecular shuttles. Biotechnol. Bioeng. 104(6): 1182-1188.
- Carroll-Portillo, A., Bachand, M., Greene, A.C, and Bachand, G.D. (2009). Capture and transport of protein analytes with kinesin-based nanoharvesters. Small 5(16): 1835-1840.
- Bachand, G.D., Hess, H., Ratna, B., Satir, P., and Vogel, V. (2009). “Smart Dust” biosensors powered by biomolecular motors. Lab Chip 9(12): 1661 – 1666 (Invited review).
- Tucker, R. Saha, A., Katira, P., Bachand, M., Bachand, G.D., and Hess, H. (2009). Temperature-compensation for hybrid devices: Kinesin’s Km is temperature-independent. Small 5(11): 1279-1282.
- Rios, L. and Bachand, G.D. (2009). Multiplex transport and detection of cytokines using kinesin-driven molecular shuttles. Lab Chip 9: 1005-1010.
- Liu, H., Spoerke, E.D., Bachand, M., Koch, S.J., Bunker, B.C., and Bachand, G.D. (2008). Dynamic self-assembly of nanocomposite structures through the interaction of thermodynamic and energy-dissipating processes. Adv. Mater. 20(23): 4476–4481.
Selected User Projects
- Temperature Compensation of Kinesin-Powered Molecular Shuttle Velocity, Henry Hess, Columbia University
- Modeling of Elasto-Mechanical Phenomena Involved in the Motor-Driven Assembly of Nanomaterials, Alan Barhorst, Texas Tech University