Peter M. Goodwin

Scientist, Center for Integrated Nanotechnologies
Science Thrust: Soft, Biological and Composite Nanomaterials

Phone 505-665-2506
Fax 505-665-9030

Los Alamos National Laboratory
Los Alamos, NM 87545


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Education and Training

Undergraduate: California Institute of Technology, BS, Physics, 1980
Graduate: Cornell University, M.S., Applied Physics, 1984
Graduate: Cornell University, Ph.D., Applied Physics, 1989


My research interests are primarily in the area of single-molecule spectroscopy and high-resolution optical imaging. I am working on the development of correlated atomic force and single-molecule fluorescence imaging and the development of techniques to allow simultaneous single-molecule force-extension and fluorescence measurements. Other areas of active research include: single-molecule imaging of cellulase activity on cellulose and single-molecule studies of riboswitch conformational dynamics.

Selected Publications

  • Going beyond 2D: following membrane diffusion and topography in the IgE-Fc[epsilon]RI system using 3-dimensional tracking microscopy, N.P. Wells, G.A. Lessard, M.E. Phipps, P.M. Goodwin, D.S. Lidke, B.S. Wilson, J.H. Werner, Proc. SPIE, 7185, (2009).
  • Base-directed formation of fluorescent silver clusters, B.S. Sengupta, C.M. Ritchie, J.G. Buckman, K.R. Johnsen, P.M. Goodwin, J.T. Petty, J. Phys. Chem. C, 112(48):18776-18782 (2008).
  • Three-dimensional tracking of individual quantum dots, G.A. Lessard, P.M. Goodwin, J.H. Werner, Appl. Phys. Lett., 91:221406 (2007).
  • A comparison of the fluorescence dynamics of single molecules of a green fluorescent protein: one- versus two-photon excitation, M. Cotlet, P.M. Goodwin, G.S. Waldo, J.H. Werner, ChemPhysChem, 7(1):250-260 (2006).
  • A two-dimensional view of the folding energy landscape of cytochrome c, J.H. Werner, R. Joggerst, R.B. Dyer, P.M. Goodwin, Proc. Natl. Acad. Sci. USA, 103(30):11130-111(2006).
  • Single particle high resolution spectral analysis flow cytometry, G.G. Goddard, J.C. Martin, M. Naivar, P.M. Goodwin, S.W. Graves, R. Habbersett, J.P. Nolan, J.H. Jett, Cytometry A, 69a(8): 842-851 (2006).

Selected User Projects:

  • Investigating Telomere Structure and Function by Atomic Force Microscopy and Fluorescence Microscopy, Edwin Goodwin, KromaTid, Inc.
  • Design principles of RNA-based molecular switches, Kevin Sanbonmatsu, Los Alamos National Laboratory.
  • Single Molecule Spectroscopy and Microscopy of Semiconductor Quantum Dot Clusters, Alan Van Orden, Colorado State University.